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Peptide Engineering Laboratory
Kyung-Soo Hahm
Head
Kyung-Soo Hahm,
Endowed Professor of Medicine,
Chosun University
Phone:
82-62-230-7556
FAX: 82-62-227-8345
E-mail:
kshahm@chosun.ac.kr
Education
-1965-1969
Yonsei University, Seoul,
Korea, BS in Chemistry
-1973-1975
North Carolina Central University,
Durham, N.C., U.S.A.
MS in Organic Chemistry
-1975-1979
Duquesne University,
Pittsburgh, Pa, U.S.A. Ph.D.
in
Biochemistry
Professional
Experience
-1982
- 1986 : Associate Professor
at Yonsei University Medical
School
-1991 - 1993 :
Senior Director at the Korea
Institute of Bioscience
&
Biotechnology
(KRIBB)
-1998 - 1999
:
R&D Program Director
in Life Science & Medical
Sciences
at the Korea Institute of
S&T Evaluation &
Planning(KISTEP)
Laboratory
Staff
Yoonkyung Park,
Ph. D. (Research Professor)
Background
on Research Area
The
peptides are important bioactive
materials acting as hormones,
growth factor, and antibiotics.
Antimicrobial peptides are
widely distributed in nature
including insects, horseshoe
crabs, frogs, and mammals,
which have been known to
play important roles in
insect immunity and host
defense.
In order to
search and design highly
potent antimicrobial peptides
with lowered or no cytotoxic
activity, the structure
and antimicrobial activity
relationships have been
investigated.
The results
of these study will be applied
to the developments of the
antimicrobial, antitumor,
and antiviral peptides which
can be used as pharmaceuticals,
agrochemicals, nutraceuticals,
food additives, cosmetics,
and etc.
Specific
Aims
Design and synthesis
of the hybrid and analogue
peptides : Novel analogue
peptides based on the structure
of various known antimicrobial
peptides including CA, MA,
ME, PMAP-23, CA-MA hybrid,
CA-ME hybrid will be designed
and synthesized in order
to develop antimicrobial
agents against bacteria,
fungi, virus, and tumor
cells.
Screening
of new functional peptides
: New functional peptides
will be screened and isolated
from microorganisms, plants,
and animals and will be
investigated the structure
and antibiotic activity.
Establishment of peptide
library : Synthesized and
isolated peptides will be
deposited to the peptide
library systematically and
distributed it and related
bioinformatics to the researcher.
Ribbon
diagram of the restrained
minimized mean structure of
a) CA(1-8)-MA(1-12)
in TFE/water solution
b)
CA(1-8)-MA(1-12) in DPC
micelle
c) CA(1-8)-ME(1-12)
in TFE/water solution and
d)
CA(1-8)-ME(1-12) in DPC
micelle.
Selected
Publications
1. Shin
SY, Kang JH, Jang SY, Kim
Y, Kim KL, and Hahm K-S.
(2000) Effects of the Hinge
Region of Cecropin A(1-8)-Magainin
2(1-12), a Synthetic Antimicrobial
Peptide on Liposomes, Bacterial
and Tumor Cells. Biochim.
Biophys.Acta. 1463,
209-218.
2. Lee DG,
Kim DH., Park Y, Kim HK,
Kim HN, Shin YK, Choi CH,
and Hahm K-S. (2001) Fungicidal
Effect of Antimicrobial
Peptide, PMAP-23 Isolated
from Porcine Myeloid against
Candida albicans. Biochem.
Biophys. Res. Commun., 282,
570-574.
3. Lee DG,
Park Y, Kim HN, Kim, HK,
Kim, PI, Choi, BH, and Hahm
K-S. (2002) Antifungal Mechanism
of an Antimicrobial Peptide,
HP(2-20), Derived from N-Terminus
of Helicobacter pylori
Ribosomal Protein L1 against
Candida albicans. Biochem.
Biophys. Res. Commun. 291,
1006-1013.
4. Kim
HK, Lee DG, Park Y, Kim
HN, Choi BH, Choi C-H, and
Hahm K-S. (2002) Antibacterial
Activities of Peptides Designed
as Hybrids of Antimicrobial
Peptides. Biotechnol. Lett.
24, 347-353.
5. Lee
DG, Kim PI, Park Y, Woo
E-R, Choi JS, Choi C-H,
and Hahm K-S. (2002) Design
of Novel Peptide Analogues
with Potent Fungicidal Activity,
Based on PMAP-23 Antimicrobial
Peptide Isolated from Porcine
Myeloid. Biochem.
Biophys.
Res. Commun. 293, 231-238.
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